Whether or not you see the tick bite or the classic Lyme rash, your early symptoms are likely to be flu-like. Symptoms are often cyclical, waxing and waning every few weeks (12). Tiredness, exhaustion, and lack of energy are the most frequent symptoms. The Lyme fatigue can seem different from regular tiredness, where you can point to activity as a cause. This fatigue seems to take over your body and can be severe. You may find yourself needing a nap during the day or needing to sleep one or more hours longer than usual. In one study, about 84 percent of children with Lyme reported fatigue (8). In a 2013 study of adults with Lyme, 76 percent reported fatigue (15). Sometimes Lyme-related fatigue is misdiagnosed as chronic fatigue syndrome, fibromyalgia, or depression (8). In some Lyme cases, fatigue can be disabling (16).